{"id":169,"date":"2026-10-29T10:27:52","date_gmt":"2026-10-29T10:27:52","guid":{"rendered":"https:\/\/yourmedsuk.com\/insights\/zopiclone-what-happens-if-you-stay-awake\/"},"modified":"2026-10-30T10:31:21","modified_gmt":"2026-10-30T10:31:21","slug":"zopiclone-what-happens-if-you-stay-awake","status":"publish","type":"post","link":"https:\/\/yourmedsuk.com\/insights\/zopiclone-what-happens-if-you-stay-awake\/","title":{"rendered":"What happens if you take zopiclone and stay awake?"},"content":{"rendered":"<div class=\"ym-article\">\n<p class=\"ym-answer\">What happens if you take zopiclone and stay awake? The medicine still works on your brain even though you are not asleep. You are likely to feel very drowsy and unsteady, and you may later have no memory of what you did. UK product information also warns of sleepwalking and &#8220;sleep-driving&#8221;. That is why you should only take zopiclone when you are going straight to bed for a full night.<\/p>\n<div class=\"ym-facts\">\n<h2>Key facts<\/h2>\n<ul>\n<li><strong>What it is:<\/strong> Zopiclone is a &#8220;Z-drug&#8221; sleeping tablet (a hypnotic).<\/li>\n<li><strong>Licensed use (UK):<\/strong> Short-term treatment of insomnia in adults.<\/li>\n<li><strong>Legal status:<\/strong> Class C controlled drug, Schedule 4 Part 1.<\/li>\n<li><strong>Needs a prescription:<\/strong> Yes<\/li>\n<li><strong>When to take it:<\/strong> Once a night, just before bed, with 7 to 8 hours free for sleep<\/li>\n<li><strong>If it does not work:<\/strong> Never take a second dose the same night<\/li>\n<li><strong>Last checked:<\/strong> October 2026<\/li>\n<\/ul>\n<\/div>\n<p>This guide explains what happens if you take zopiclone and then stay up, what to do if it does not seem to work, and when you need help. Every fact comes from UK product information, the NHS, NICE or regulators. Always take zopiclone exactly as your prescriber tells you. For the basics, start with our <a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone\/\">complete guide to zopiclone<\/a>.<\/p>\n<h2 id=\"stay-awake\">What happens if you take zopiclone and stay awake?<\/h2>\n<p>Zopiclone is designed to be taken at the moment you settle down to sleep. The <a href=\"https:\/\/www.nhs.uk\/medicines\/zopiclone\/about-zopiclone\/\">NHS says it takes around 30 to 60 minutes<\/a> to start working. If you are still up and about at that point, the sedative effect does not simply wear off. Here is what UK product information says can happen.<\/p>\n<h3>You feel very drowsy and unsteady<\/h3>\n<p>Drowsiness is one of the most common effects of zopiclone. When you fight it, you may feel dazed, slow and less coordinated. The <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101510\/smpc\">Grindeks zopiclone 7.5 mg SmPC<\/a> warns of a risk of falls, especially in older adults who get up during the night.<\/p>\n<h3>You may not remember what you did<\/h3>\n<p>Zopiclone can cause short-term memory loss called anterograde amnesia. This means you may not form memories of events after taking the tablet. The Grindeks SmPC says it is more likely if your sleep is interrupted or your bedtime is delayed after taking it. It can appear within hours of the dose.<\/p>\n<p>The <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101509\/pil\">Grindeks patient leaflet<\/a> puts it simply: memory loss is most likely a few hours after taking the tablet. Its advice is to take zopiclone just before or after going to bed, and to make sure you can have 7 to 8 hours of uninterrupted sleep.<\/p>\n<h3>You could do things while not fully awake<\/h3>\n<p>The most serious risk is a group of effects called complex sleep behaviours. The <a href=\"https:\/\/www.nhs.uk\/medicines\/zopiclone\/side-effects-of-zopiclone\/\">NHS lists sleepwalking or doing things while not fully awake<\/a> as a serious side effect. Examples include eating, talking on the phone or driving.<\/p>\n<p>The SmPCs describe the same thing: sleepwalking, &#8220;sleep driving&#8221;, preparing and eating food, or making phone calls, with no memory of the event afterwards. The Grindeks SmPC says this can happen after the first dose or any later dose. People can seriously injure themselves or others, and such injuries can be fatal.<\/p>\n<p>According to the <a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101311\/smpc\">SmPC for zopiclone 7.5 mg tablets<\/a>, the risk appears to rise if you:<\/p>\n<ul>\n<li>drink alcohol with zopiclone<\/li>\n<li>take other medicines that slow down the brain, such as other sleeping tablets or opioid painkillers<\/li>\n<li>take more than the maximum recommended dose<\/li>\n<\/ul>\n<h3>Unusual or out-of-character reactions<\/h3>\n<p>Both SmPCs describe &#8220;paradoxical&#8221; reactions. These include restlessness, agitation, irritability, aggression, nightmares, hallucinations and inappropriate behaviour. They are more likely in older adults. If they happen, the SmPCs say zopiclone should be stopped, so speak to your prescriber.<\/p>\n<h2 id=\"evidence\">How serious are complex sleep behaviours?<\/h2>\n<p>These events are uncommon. The Grindeks SmPC lists amnesia and hallucinations as rare (affecting up to 1 in 1,000 people). It lists complex sleep behaviours as &#8220;not known&#8221;, meaning the frequency cannot be estimated from the data.<\/p>\n<p>Regulators still take them seriously. In 2019 the <a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-adds-boxed-warning-risk-serious-injuries-caused-sleepwalking-certain-prescription-insomnia\">US Food and Drug Administration added its strongest warning<\/a> to three related medicines: eszopiclone, zaleplon and zolpidem. It had identified 66 cases of complex sleep behaviours causing serious injury, including 20 deaths. The FDA said these can happen even at the lowest recommended dose and after just one dose.<\/p>\n<p>Zopiclone itself was not part of that review, because it is not sold in the US. But eszopiclone is closely related to it. In the UK, the Grindeks SmPC now lists a previous episode of complex sleep behaviour after zopiclone as a reason not to take it again.<\/p>\n<h2 id=\"what-to-do\">What to do if you have taken zopiclone and cannot sleep<\/h2>\n<p>If you have taken your dose and are still awake, these steps follow the official UK advice:<\/p>\n<ol>\n<li><strong>Go to bed and stay there.<\/strong> Lie down in a dark, quiet room. Avoid stairs, cooking or anything that needs care.<\/li>\n<li><strong>Do not take another tablet.<\/strong> The NHS says do not take more than 1 dose in the same night, and that an extra dose can be dangerous.<\/li>\n<li><strong>Do not drink alcohol.<\/strong> The NHS warns that alcohol with zopiclone can cause breathing problems and make it very hard to wake up.<\/li>\n<li><strong>Do not drive or go out.<\/strong> UK product information recommends at least 12 hours between taking zopiclone and driving or using machines.<\/li>\n<li><strong>Tell someone you live with.<\/strong> If they notice you doing things while not fully awake, they can keep you safe and tell you in the morning.<\/li>\n<li><strong>Talk to your prescriber<\/strong> if this happens more than once, rather than changing how you take it yourself.<\/li>\n<\/ol>\n<p>If you forgot to take it at bedtime, the NHS says to skip the missed dose and take the next one at bedtime the next day. The Grindeks leaflet says you can still take it if you have 7 to 8 hours left for sleep. Never take a double dose.<\/p>\n<h2 id=\"not-working\">Zopiclone not working: why it might happen<\/h2>\n<p>Feeling wide awake after zopiclone is frustrating, but there is usually a reason. Our guide to <a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-how-long-does-it-take-to-work\/\">how long zopiclone takes to work<\/a> explains the timings in more detail.<\/p>\n<h3>Zopiclone not working after 2 hours<\/h3>\n<p>The level in your blood peaks about 1.5 to 2 hours after a dose, according to the SmPC. So if you are still awake at 2 hours, the full effect has already arrived. Taking more will not help you sleep safely. The SmPCs say zopiclone is taken in a single intake and must not be taken again during the same night.<\/p>\n<p>A second dose raises the risk of memory loss, complex sleep behaviours and next-day drowsiness. If you are often still awake 2 hours after your dose, tell your prescriber.<\/p>\n<h3>Zopiclone not working the first time<\/h3>\n<p>Some people do not respond fully to the first dose. Timing and setting matter. The Grindeks SmPC says to take the tablet upright, just before bedtime or when already in bed. Taking it earlier and staying up works against it.<\/p>\n<p>Starting doses also differ. The Grindeks SmPC gives a usual starting dose of 5 mg, which a prescriber may increase to 7.5 mg if needed. It says the dose should not exceed 7.5 mg a day. Only your prescriber should change your dose. Our <a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-dose\/\">zopiclone dose guide<\/a> explains the strengths.<\/p>\n<h3>Zopiclone stopped working after a few weeks<\/h3>\n<p>Your body can get used to sleeping tablets. The NHS says zopiclone is usually not prescribed for more than 4 weeks, partly because it can stop working as well. The 7.5 mg SmPC says some loss of effect may develop after repeated use for a few weeks.<\/p>\n<p>Do not increase your dose or stop suddenly. Stopping suddenly can cause withdrawal symptoms and rebound insomnia, where sleep problems come back worse for a short time. Your doctor will reduce the dose gradually if needed. Read more about the <a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-withdrawal\/\">withdrawal symptoms of zopiclone<\/a> and how a gradual reduction works.<\/p>\n<h3>What your doctor may suggest instead<\/h3>\n<p><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta77\">NICE guidance on zaleplon, zolpidem and zopiclone<\/a> says doctors should consider non-medicine treatments first. If a sleeping tablet is used, it should be for short periods only. NICE also says that if one of these medicines does not work, the doctor should not prescribe another of the three. Our <a href=\"https:\/\/yourmedsuk.com\/insights\/insomnia\/\">insomnia guide<\/a> covers non-medicine options.<\/p>\n<h2 id=\"who-should-not\">Who should not take zopiclone again?<\/h2>\n<p>If you have ever sleepwalked or done anything else while not fully awake after taking zopiclone, tell your prescriber. The Grindeks SmPC and leaflet say you must not take it again after this. The 7.5 mg SmPC says stopping treatment should be strongly considered.<\/p>\n<p>The NHS also says zopiclone is not suitable for some people, including those with sleep apnoea or other breathing problems, myasthenia gravis, liver problems, or a past addiction to alcohol or drugs. See our guide to <a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-side-effects\/\">zopiclone side effects<\/a> for the full list of effects to watch for.<\/p>\n<h2 id=\"next-day\">Driving and the next day<\/h2>\n<p>Staying up late after a dose means less time for the medicine to clear before morning. The NHS says do not drive, ride a bike or use machinery for 12 hours after taking zopiclone. If you still feel sleepy or dazed after that, wait until it passes.<\/p>\n<p>Under UK law, it is <a href=\"https:\/\/www.gov.uk\/drug-driving-law\">illegal to drive if any medicine makes you unfit to drive<\/a>, including prescribed ones. A conviction can mean at least a 1-year ban, an unlimited fine and up to 6 months in prison.<\/p>\n<h2 id=\"legal-status\">Is zopiclone a controlled drug?<\/h2>\n<p>Yes. Zopiclone was made a <a href=\"https:\/\/www.legislation.gov.uk\/uksi\/2014\/1106\/note\/made\">Class C drug under the Misuse of Drugs Act<\/a> in 2014. It was added to <a href=\"https:\/\/www.legislation.gov.uk\/uksi\/2014\/1275\/made\">Schedule 4 Part 1 from 10 June 2014<\/a>. It is only legally supplied in the UK on prescription. Read more in our guide to <a href=\"https:\/\/yourmedsuk.com\/insights\/controlled-drugs-uk-explained\/\">controlled drugs in the UK<\/a>.<\/p>\n<div class=\"ym-help\">\n<h2>When to get help<\/h2>\n<p><strong>Call 999 or go to A&amp;E now<\/strong> if someone who has taken zopiclone is very hard to wake, has slow, shallow or difficult breathing, is badly hurt after a fall or sleepwalking, or has signs of a serious allergic reaction such as a swollen face, lips, tongue or throat.<\/p>\n<p><strong>Call NHS 111 or your doctor<\/strong> if you have taken more than your prescribed dose, if you have done things while not fully awake such as eating, making calls or driving, or if you have hallucinations, very low mood or thoughts of harming yourself.<\/p>\n<p><strong>Talk to your doctor or pharmacist<\/strong> if zopiclone does not seem to work, if it has stopped working, or if you have taken it for longer than planned.<\/p>\n<p>You can report a suspected side effect to the MHRA through the <a href=\"https:\/\/yellowcard.mhra.gov.uk\/\">Yellow Card scheme<\/a>.<\/p>\n<\/div>\n<div class=\"ym-faq\">\n<h2>Frequently asked questions<\/h2>\n<h3>What happens if you take zopiclone and stay awake?<\/h3>\n<p>You are likely to feel very drowsy and unsteady. You may also have memory gaps, and there is a risk of doing things while not fully awake, such as eating or driving. Take it only when you are going straight to bed.<\/p>\n<h3>Why is my zopiclone not working?<\/h3>\n<p>Common reasons include taking it too early and staying up, a dose that is too low for you, or your body getting used to it after a few weeks. Talk to your prescriber rather than taking more.<\/p>\n<h3>Can I take another zopiclone if it is not working after 2 hours?<\/h3>\n<p>No. UK product information says zopiclone is taken once and must not be taken again in the same night. An extra dose can be dangerous.<\/p>\n<h3>Is it normal for zopiclone not to work the first time?<\/h3>\n<p>It can happen. Make sure you take it just before bed with 7 to 8 hours free for sleep. If it still does not help, your prescriber can review your dose or treatment.<\/p>\n<h3>Can zopiclone make you sleepwalk?<\/h3>\n<p>Yes, although it is uncommon. Sleepwalking and sleep-driving have been reported, sometimes after the first dose. Alcohol makes it more likely. If it happens, tell your doctor.<\/p>\n<\/div>\n<div class=\"ym-related\">\n<h2>Related guides<\/h2>\n<ul>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone\/\">Zopiclone: what it is, how it works and how it&#8217;s used<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-how-long-does-it-take-to-work\/\">Zopiclone: how long does it take to work and how long does it last?<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-dose\/\">Zopiclone dose: 3.75 mg, 5 mg and 7.5 mg explained<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-side-effects\/\">Side effects of zopiclone, including next-day effects<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/zopiclone-withdrawal\/\">Withdrawal symptoms of zopiclone: how to come off it safely<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/controlled-drugs-uk-explained\/\">Controlled drugs in the UK explained<\/a><\/li>\n<li><a href=\"https:\/\/yourmedsuk.com\/insights\/insomnia\/\">Insomnia: causes and treatment options<\/a><\/li>\n<\/ul>\n<\/div>\n<div class=\"ym-refs\">\n<h2>References<\/h2>\n<ol>\n<li><a href=\"https:\/\/www.nhs.uk\/medicines\/zopiclone\/about-zopiclone\/\">About zopiclone<\/a>, NHS, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.nhs.uk\/medicines\/zopiclone\/side-effects-of-zopiclone\/\">Side effects of zopiclone<\/a>, NHS, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101510\/smpc\">Zopiclone Grindeks 7.5 mg film-coated tablets \u2013 Summary of Product Characteristics<\/a>, electronic medicines compendium (emc), accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101311\/smpc\">Zopiclone 7.5 mg film-coated tablets \u2013 Summary of Product Characteristics<\/a>, electronic medicines compendium (emc), accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.medicines.org.uk\/emc\/product\/101509\/pil\">Zopiclone Grindeks film-coated tablets \u2013 Patient Information Leaflet<\/a>, electronic medicines compendium (emc), accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-adds-boxed-warning-risk-serious-injuries-caused-sleepwalking-certain-prescription-insomnia\">FDA adds Boxed Warning for risk of serious injuries caused by sleepwalking with certain prescription insomnia medicines<\/a>, US Food and Drug Administration, April 2019, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.nice.org.uk\/guidance\/ta77\">Guidance on the use of zaleplon, zolpidem and zopiclone for the short-term management of insomnia (TA77)<\/a>, NICE, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.gov.uk\/drug-driving-law\">Drugs and driving: the law<\/a>, GOV.UK, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.legislation.gov.uk\/uksi\/2014\/1106\/note\/made\">The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014 \u2013 Explanatory Note<\/a>, legislation.gov.uk, accessed October 2026<\/li>\n<li><a href=\"https:\/\/www.legislation.gov.uk\/uksi\/2014\/1275\/made\">The Misuse of Drugs and Misuse of Drugs (Safe Custody) (Amendment) (England, Wales and Scotland) Regulations 2014<\/a>, legislation.gov.uk, accessed October 2026<\/li>\n<li><a href=\"https:\/\/yellowcard.mhra.gov.uk\/\">Yellow Card scheme<\/a>, MHRA, accessed October 2026<\/li>\n<\/ol>\n<\/div>\n<p class=\"ym-disclaimer\">This article is for information only and does not replace advice from your doctor or pharmacist. Read our <a href=\"https:\/\/yourmedsuk.com\/insights\/medical-disclaimer\/\">medical disclaimer<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>What happens if you take zopiclone and stay up: drowsiness, memory gaps and the risk of sleepwalking or sleep-driving. Plus why you must never take a second dose, and what to do if zopiclone is not working, from official UK sources.<\/p>\n","protected":false},"author":1,"featured_media":168,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[],"class_list":["post-169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zopiclone"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What Happens If You Take Zopiclone and Stay Awake?<\/title>\n<meta name=\"description\" content=\"What happens if you take zopiclone and stay awake? 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